Abstract
The N-tosyl moiety is a robust constituent of numerous pharmaceutical molecules. It has drawn enormous attention to exploring the efficient hybridization of N-tosyl moiety with nitrogen-containing five-membered heterocyclic rings. In this chapter, we focus on N-sulfonated five-membered rings which include five important classes named N-sulfonated-pyrrole, -isoxazole, -oxazole, -isothiazole, and –thiazole derivatives. Furthermore, recent reported synthetic methodologies are focused on their synthesis as well as their intriguing biological properties. For example, N-tosyl pyrrole derivatives demonstrated anticancer and antiviral activities.
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