Abstract
A brief overview is provided of co-crystal synthesis by mechanochemical techniques, i.e. methods for chemical and supramolecular synthesis by using mechanical agitation in the absence of bulk solvent. The overview highlights mechanochemical co-crystallization as a topic at the interface of supramolecular chemistry, mechanochemistry and materials science, and provides an introduction to the fundamental concepts of such mechanochemical co-crystallization. The introduction briefly summarizes the basics of mechanochemical methodologies most commonly applied in co-crystal synthesis and discovery, and offers illustrative examples of the use of these methodologies in co-crystal screening. Also highlighted are the special, emergent advantages of mechanochemistry in co-crystal formation, in particular the high screening efficiency, excellent stoichiometric control and control over the polymorphic composition of the products. The chapter also offers an overview of the most recent developments in real-time, in situ studies by Raman spectroscopy or synchrotron X-ray powder diffraction, and gives several examples of using mechanochemical co-crystallization in the synthesis of complex multi-component materials, screening for recognition of molecules, including biomolecules, and exploring the reactivity of multi-component solids. The text provides a succinct introduction to mechanochemistry in co-crystal synthesis and is accompanied by references to more extensive review articles.
Published Version
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