Chapter 4 - Current trends in site and target specific delivery of nanomedicine for gene therapy

Abstract

Gene therapy is useful for the treatment of various genetic disorders. The fabrication of nanoparticles is the initial step to achieve the targeted drug and gene delivery. Specialized nanoparticles show significant impact value in gene delivery systems. In addition, specialized properties of nanoparticles are responsible for the achievement of site and target specific delivery of genetic materials. However, this nanoparticle mediated gene delivery has great challenges due to its reproducibility and the toxicity of host cells. The avoidance of this hurdle makes the exploitation of Trojan horses of drug and gene delivery via nanoparticle delivery system. The collective approach for understanding biological behavior of nanoparticles and nanoparticle fabrication leads to a high rate of success in translation of nanodrug and gene delivery systems. The present book chapter highlights a possible approach to the site and target specific delivery of genes via nanotechnology.