Abstract
The brain and nervous system are important targets of immunological injury in people with systemic lupus erythematosus. In contrast to other organ systems, the pathogenic mechanisms which contribute to nervous system dysfunction in lupus are relatively poorly defined. The cerebral vasculature is a particular target of lupus-related disease, and brain-reactive antibodies and neurotoxic cytokines are important factors in the development of brain, spinal cord and peripheral nervous system damage. Yet the relative contribution of each of these mechanisms to the development of neurological disease in people with lupus remains poorly defined. The identification of molecular mechanisms of neurolupus will inform the optimal treatment strategies in the future.
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