Abstract
Abstract Rat ultrasonic vocalizations are a complex sensorimotor activity, relying on coordinated interactions between neural mechanisms and the respiratory and laryngeal systems. Therefore, sensorimotor decline related to advanced age likely impacts the production of ultrasonic vocalizations and, consequently, the acoustic parameters of these vocalizations. This chapter describes the acoustic changes in the ultrasonic vocalizations reported in older rats as well as the neurodegenerative processes affecting the vocal mechanism that likely underlie those acoustic changes. These age-related changes are mostly related to multifactorial neuromuscular senescence, including sensorimotor innervation and structural and biomechanical changes in the vocal folds.
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