Abstract
Stroke marks the beginning of a cascade of molecular and cellular processes that allow for neural repair and recovery. Stroke induces changes in the excitability of neuronal circuits in peri-infarct cortex that underlie the process of remapping motor and sensory function. Axonal sprouting occurs in tissue adjacent to the stroke and its connected areas. Stroke cues support the association of angiogenic vessels with the migration of newborn neurons into the peri-infarct area in a neurovascular unit. Neurogenesis, angiogenesis, and axonal sprouting support neurologic recovery after stroke. This chapter focuses on the fundamental mechanisms and timing of stroke recovery.
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