Abstract
Depression is one of the most prevalent and persistent psychiatric disorder that severely affects psychosocial functioning, thereby reducing the quality of life. Depression is a consequence of heterogeneous etiologies and therefore the mechanisms underlying the depression remain unclear. Recent studies suggest that neoplastic changes in specific neural circuits play a key role in the pathogenesis of depression. Neurotrophins including nerve growth factor (NGF) regulate activity-dependent neuroplasticity ensuring the survival of neurons and neurites during the development. Aberrant NGF levels have been implicated in the complex etiopathogenesis of depression and antidepressant treatments by modulating the neuroplasticity in specific brain neurocircuits. Therefore, either up or downregulation of NGF signaling may be a promising prospect for the novel antidepressant treatments. NGF modulation might provide more insights into understanding the role of neuroplasticity in the pathophysiology of depression and help in efficient targeted treatment strategies for depression in the future.
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