Abstract
The emergence and course of major depressive disorders (MDD) show a clear causal relationship with the dysregulation and dysfunction of the immune system. Systemic and neural low-grade chronic or acute inflammation initiates and perpetuates MDD psychopathology. Proinflammatory factors, released into the circulation by brain-intrinsic immune regulatory cells (microglia and astroglia) and immune cells entering the CNS (T- and B-cells, neutrophils, dendritic cells, etc.) trigger changes in neural circuits and function. Chronic stress, which strongly contributes to MDD, is known to suppress protective immune responses and/or exacerbate pathological immune responses.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
