Abstract
Life on earth is dynamic in nature, and all plants and animals closely associate with symbiotics and commensal microorganisms (microbiota). Soil-dwelling nematode Caenorhabditis elegans (C. elegans) is a well-established model for studying host–microbe interaction, immunity, neurobiology, longevity, etc. However, very little research has been conducted on C. elegans to understand host–microbe interaction in the worm's natural habitat and reveal the role of the native microbiome in the worm's fitness. Systemic analysis of the worm's native microbiome has shown great relevance in the worm's development, immunity, lifespan, and aging. Besides, microorganisms associated with the worm's gut may also impact host physiology and protect against pathogenic microbes like bacteria and fungi in the worm's ecological niches. Therefore, an intense study is required to understand the complex interaction between worms and associated microbiota in the natural habitat, which helps develop microbiota-based therapeutics to cure various human diseases.
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