Abstract
Cancer therapy requires the management of hyperleukocytosis and tumor lysis syndrome (TLS), hypercalcemia, syndrome of inappropriate antidiuretic hormone secretion/hyponatremia, superior vena cava syndrome and mediastinal masses, acute abdominal processes,and neurologic emergencies. Oncologic emergencies can occur as an initial manifestation of cancer, as a side effect of therapy, or at the time of progression or recurrence of the disease and arise as a result of metabolic and endocrine disturbances that result from malignancy or are secondary to therapy, or due to space-occupying lesions that can press on or obstruct vital organs and cause mechanical or surgical emergencies or due to pancytopenia secondary to bone marrow replacement or chemotherapy that may result in hemorrhage, anemia and susceptibility to overwhelming infection. Survival in children with cancer has increased dramatically during the past five decades. This progress is due not only to advances in specific oncologic therapies, but also to advances in supportive care and an improved ability to manage life-threatening complications.
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