Abstract
The synthesis of isocoumarins has been carried out by using a range of methods including traditional or transition metal–catalyzed reactions. The alkyne-based methodologies have emerged as a popular synthetic approach to this class of compounds, and a number of transition metal catalysts including salts or complexes of Cu, Pd, Ag, Hg, Ru, Rh, Ni, or Ir have been explored for this purpose. A considerable effort has been devoted during the past decades to develop new and efficient synthetic routes to obtain isocoumarin derivatives with different substitution patterns. Recently, the transition metal–catalyzed ortho C–H activation of benzoic acid derivatives directed by the carboxylate group has attracted considerable interest as an attractive approach to isocoumarins. An overview of all these methodologies will be presented in the chapter.
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