Abstract
Over the years, natural products have been a major source of various and structurally diverse isocoumarin derivatives mostly in the form of secondary metabolites. These are produced via a pathway called secondary metabolism and, unlike primary metabolites, they do not have apparent utility for the survival and well-being of the organisms. The natural sources, selected examples, and representative biosynthesis of these derivatives are presented in the following sections. Various examples of bioactive isocoumarins and their biological properties are also presented in this chapter.
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