Chapter 3 - SERS probes and tags for biomedical applications

Abstract

Imaging and diagnostic techniques based on Surface-enhanced Raman scattering (SERS) are emerging as a potential alternative to the current medical standard practices. SERS-based techniques can offer a cheap and reliable alternative to these current standard methods, especially for point-of-care (POC) applications. The translation of SERS into clinical practice will provide clinicians with additional tools that can be used to complement their current toolbox and to expand the reach of standard imaging and diagnostic methods. However, the design of optimal SERS technology is a complex task and requires understanding of this phenomenon. The goal of this chapter is to give the reader the basic knowledge necessary for the design of SERS methods with a focus on POC applications In this chapter, we provide the basis for the use of SERS in point-of-care application. We discuss important aspects in the design of SERS probes and tags, such as the nanoparticle type, Raman reporter and surface coating. We also discuss how SERS has been used in sensor using different sensing mechanism, highlighting the principles and applications of various methods.