Abstract
Normal puberty is controlled by the higher centers of the central nervous system which regulate the activity of the hypothalamic–pituitary axis, which in turn stimulates the gonads to secrete sex steroids which bring about the physical changes of puberty. This physiology originates during the fetal stage and ends in senescence. Thus puberty represents one stage in the progression to reproductive maturity. The development of gonadotropin-releasing hormone agonists for delaying pubertal development in transgender youth was based on the normal physiology of the hypothalamic–pituitary–gonadal axis. This chapter outlines this basic control of the onset of puberty and physical changes of puberty, and briefly mentions abnormalities of puberty that may develop with a disturbance in the normal physiology.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
