Abstract
Recent advances in microfluidic cell culture systems have led to major interest in controlling the spatiotemporal microenvironment within microscale geometries. Microfluidic systems are well suited for culturing, probing, and analyzing living cells. As such, there has been growing interest to develop novel methods for direct on-chip detection of biomolecules, and to characterize the transport processes of these biomolecules within the microfluidic system. Here, this chapter discusses theoretical and numerical modeling and the latest advances in the measurement and characterization of biomolecules within confined microfluidic geometries, with an emphasis on transient convection, diffusion, adsorption and binding of biomolecules with application toward biomedical applications via surface-based biosensors. Fundamental principles of fluid flow, molecular transport phenomena, and reaction kinetics are described in detail to provide a framework for modeling microfluidic systems designed for cell culture and biological analyses.
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