Chapter 3 Chromatographic Sample Introduction for Plasma Mass Spectrometry

Abstract

This chapter discusses the use of plasma mass spectrometry for the detection of chromatographic eluates. The combination of high performance liquid chromatography (HPLC) with inductively coupled plasma mass spectrometry (ICP–MS) detection provides an analytical technique capable of providing species selectivity and sub-ng levels of detection. The superior detection levels, as compared to atomic emission techniques, should spur the development of both HPLC and gas chromatography (GC) procedures capable of speciating trace elements in environmental and clinical samples. The use of a helium microwave plasma source is described. Several investigations have demonstrated the potential advantages of He microwave-induced plasma mass spectrometry (MIP–MS) for GC detection of halogenated compounds. Chromatographic detection using plasma mass spectrometry exhibits tremendous potential; however, further studies are necessary. Multielement detection and isotope ratio determinations on eluting peaks are of considerable interest. In addition, the use of plasma sources other than the argon ICP should prove beneficial for the determination of non-metal species separated by HPLC. Both sample introduction to the plasma and the interface between the chromatograph and plasma mass spectrometer should be areas of future research.