Chapter 3 - Biosensors: a better biomarker for diseases diagnosis

Abstract

The studies of biosensors are attracting special interest because of their role in detecting and monitoring different types of diseases for medical applications. These are the devices designed to detect a specific biological analysis by converting a biological entity into an electrical signal that can be detected and analyzed. Although there have been many progresses in therapeutics in the past decades, an early diagnosis is considered to be a major integral part for treatment of diseases. The current chapter focused on the discussion of development and research of various types of biomarkers which are basically used for the detection and diagnosis of diseases. Herein, we studied the interaction of different proteins (PDB ID: 4MPF and 3D78) with halauxifen-methyl, mesosulfuron-methyl andibutyl benzene-1,2-dicarboxylate, and 1,2-dimethoxy-4-prop-2-enylbenzene by molecular docking method. It was observed that mesosulfuron-methyl ligand was showing more preferential interaction toward 4MPF compared to halauxifen-methyl. However, between dibutyl benzene-1,2-dicarboxylate and 1,2-dimethoxy-4-prop-2-enylbenzene the former was showing best binding interaction toward 3D78. The binding energy specified that dibutyl benzene-1,2-dicarboxylate could perform better sensing strength toward 3D78.