Abstract
Lipids play critical roles in cancer biology, strategies involving lipid metabolites and the metabolic enzymes can be used to treat and prevent cancer. In vitro and animal studies recently identified some of the mechanisms of n−3 polyunsaturated fatty acids (PUFAs) besides the potential molecular targets. n−3 Fatty acids supplementation is widely employed in cancer patients, mainly as an adjunctive treatment. The identification of proresolution mediators derived from n−3 fatty acids opened up various therapeutic possibilities for different pathologies. There is no enough reliable data regarding whether n−3 PUFAs can significantly prevent cancer-related complications, depending on the cancer stage, from dysplasia to carcinoma and metastasis. However, increased knowledge of the role played by bioactive lipids will provide a novel opportunity to eliminate these highly aggressive cells.
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