Abstract
The nonhuman primate (NHP) has become particularly important in drug discovery research and development both in terms of safety and efficacy evaluation. Often, NHPs represent the most appropriate species for drug development and research because of their phylogenic relationship to humans or other key attributes such as pharmacokinetics. Understanding the potential for novel drugs to interact with and affect the cardiovascular system remains an important safety issue in drug development. This chapter reviews the basics of the NHP cardiovascular system, including a brief review of normal cardiovascular physiology. The multiple models used to assess cardiovascular structure and function in the NHP, primarily in safety assessment, are summarized. Advanced or emerging technologies available to monitor the cardiovascular system are identified when appropriate. The overall goal is to provide the reader with an overview of the tools and models available to successfully analyze the cardiovascular system of the NHP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
