Abstract
Polyphenols give color and photo protection to plants. In adequate amounts polyphenolic flavanoids and flavanols promote health as ascorbate synergistic antioxidants. This review examines the virtues of various polyphenols. The literature suggests quercetin dihydrate flavanoid and soluble oligomeric/orthoproanthocyanidin (OPC) flavanol, with or without ellagic acid, as the “dream team” that supports safer, more effective protection from free radical damage. Tests for antioxidant potency, such as ORAC, and research evidence on functional benefits of these nutrients are presented and discussed. The review includes key predictive biomarkers that can be used as valuable tools in clinical assessment of risk and resilience, of need and of sufficiency. The increasing total oxidative load on the body (allostatic load) and the reduction in the general availability of diet-sourced antioxidants strongly suggest the need for safer polyphenolic supplements. Biochemical individuality also supports supplement use in meaningful amounts as assessed by granulocyte function or individual repair effectiveness, and monitored through the eight predictive biomarker lab tests that help determine individual essential nutrient need. Predictive biomarker tests are more sensitive, specific, and predictive when interpreted or referenced to best outcome goal values.
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