Abstract
A variety of medications can cause ulcerative or nonulcerative inflammation throughout the gastrointestinal (GI) tract. The long-term use of some of the agents can even cause strictures and perforation. Clinical, endoscopic, histologic, and radiographic features of drug-induced GI injury can mimic that in inflammatory bowel disease (IBD). In addition, some of these medications are used in patients with IBD for the treatment of IBD-associated complications or other comorbidities. Differential diagnosis of IBD, medication-associated GI injury, and superimposed drug-induced injury in IBD are critical for the management and prognosis. Endoscopy with biopsy along with clinical history is critical for the diagnosis and differential diagnosis.
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