Abstract
Obesity and osteoporosis share several common genetic and environmental factors. A substantial body of evidence indicates that fat mass may have beneficial effects on bone. However, the latest epidemiologic and clinical studies have shown that a high level of fat mass might also be a risk factor for osteoporosis and fragility fractures. The common precursor stem cell leads to the differentiation of both adipocytes and osteoblasts. The secretion of adipocytes-derived hormones that affect bone development may partially explain these associations. Furthermore, the increasing evidence also seems to indicate that different components of the metabolic syndrome, such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also potential risk factors for the development of low bone mineral density and osteoporosis.
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