Abstract
Alpha-synuclein (α-Syn) is crucial to the pathogenesis of Parkinson's disease (PD). Mutations in α-Syn gene are found in the familial forms of PD. Aggregated and posttranslationally modified α-Syn has been identified as a major component of Lewy bodies and Lewy neurites, the hallmark of the disease in both genetic and sporadic PD. In addition to α-Syn deposition, an increasing body of evidence suggests that chronic neuroinflammation might contribute prominently to the progression of PD. Recent discoveries have unveiled that α-Syn is not only critical for neuronal events taking place in the disease but also for the activation of the immune response in PD. Here we provide an overview of the implication of α-Syn pathology and its consequences on neuroinflammation in PD.
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