Abstract
The evaluation of herbal extracts’ toxicity profiles are crucial when validating their therapeutic potential. Hence, an in vitro model using embryonic dorsal aorta region from day 11 mice embryo and cKit+ cells from B6 mice bone marrow was used to evaluate the hematotoxicity of three Mauritian endemic medicinal plants. At high concentration, all three extracts exhibited a significant (P=.001) drop in the adult’s hematopoietic stem cell number. At the highest dose tested both Acalypha integrifolia (P=.001) and Labourdonaisia glauca Bojer (P=.002) decreased the total cell number of adult progenitors, while no significant change was observed following treatment with Eugenia tinifolia. Only A. integrifolia caused a significant (P=.001) decline in embryonic total cell number. Moreover, A. integrifolia reduced the progenitor/stem cell number in both models. At a low dose, A. integrifolia induced development of lymphoid cell lineages while E. tinifolia upregulated the production of both erythroid and myeloid cells.
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