Abstract
Embryonic spinal cord tissue has been used as a source of progenitors for spinal cord injury repair for more than 30years. The earliest experimental studies successfully demonstrated that cells obtained from fetal spinal cord (FSC) tissue thrive and integrate anatomically and functionally with the surrounding neuropil of the injured adult host spinal cord. In recent years, efforts to expand the progenitor cell populations and parallel studies to identify alternative cell sources have combined in improved methods and renewed enthusiasm for the possibility of using immature neural stem cells and progenitors to enable functional repair of gray matter damage. This chapter provides a historical context of the use of FSC tissue as a tool for examining strategies aimed at replacing or amplifying interneuronal populations in the injured spinal cord. A brief discussion follows of the potential and future goals for developing neural progenitors for individualized approaches to modify and improve functional recovery after spinal cord injury.
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