Abstract

Abstract The chapter describes two anatomically and neurochemically distinct ascending tegmental reticular systems that are responsible for the initiation and maintenance of emotional arousal and, eventually, the development of the emotional state. The initiation of emotional arousal in rats is accompanied by the emission of valence-specific ultrasonic vocalizations (USVs) that served as a measure of this arousal. Activity of the ascending mesolimbic cholinergic system initiates the aversive (negative) arousal and subsequent emission of 22-kHz USVs while the activity of the ascending mesolimbic dopaminergic system initiates the appetitive (positive) arousal and subsequent emission of 50-kHz USVs. The chapter describes anatomical localization, projections, terminal regions, and functions of the mesolimbic cholinergic system from the laterodorsal tegmental nucleus and the mesolimbic dopaminergic system from the ventral tegmental area.

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