Abstract
Neocortical neurons will assemble into exquisite circuits that will ultimately drive multiple advanced functions such as higher cognition, voluntary motor behavior, and conscious sensory perception. To achieve this, a fundamental set of intricate events has to occur that will bring glutamatergic excitatory projection neurons (also called pyramidal neurons) and GABAergic inhibitory (also called interneurons) from their birth sites using two coexistent but distinct modes of migration. Neocortical glutamatergic neurons use radial migration, whereas GABAergic neurons use tangential migration. Each of the two migration mechanisms has multiple cellular steps that are regulated by intricate molecular events. This chapter summarizes current state of knowledge in transcriptional and posttranscriptional mechanisms involved in the control of radial and tangential migration of neocortical neurons.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Cellular Migration and Formation of Axons and Dendrites
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
