Abstract
Epigenetic changes are reversible but heritable events. They control the accessibility of DNA to elements of the transcriptional complex, including transcription factors and RNA polymerases. Thereby, epigenetic events orchestrate gene expression in a tissue-specific manner. Currently known key epigenetic events include DNA methylation, DNA hydroxymethylation, and histone modifications. Altered epigenetic patterns contribute to the pathophysiology of autoimmune/inflammatory disorders. Since epigenetic marks are subject to change and can be modified, they promise potential as targets in individualized therapeutic interventions. Indeed, already routinely applied therapies can modify epigenetic patterns. Here the potential of epigenetic therapies in autoimmune/inflammatory disease will be discussed in the context of the available literature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
