Abstract
Amongst various natural biopolymers, silk-based biomaterial has achieved pronounced consideration in biomedical fields. Silk-based biomaterial mainly comprises sericin and fibroin that are bestowed with several properties, such as facile fabrication, biocompatibility, biodegradability, noncytotoxic, nonimmunogenic, easy surface modification, and stability. These biomaterials holds the ability to modify drug release pattern and can be employed in formulating sustained, controlled, pH-triggered, and targeted drug delivery systems that avoid degradation and release of drug during transit before reaching a specific site. All these merits of Silk-based nanoparticles (NPs) ultimately proved them as a suitable and potential biomaterial for numerous biomedical and therapeutic applications. In recent years, numerous pieces of literature, have suggested silk-based nanomaterials for various applications formulated as NPs, nanofibers, nanocomposites, nanocomplexes, scaffolds, films, mats, etc., and have been investigated for their drug delivery and therapeutic potential. These nanomaterials have been also widely utilized for tissue regeneration, enzyme immobilization, biosensing, and bioimaging applications. This chapter describes several Silk-based nanomaterials specifically developed for drug delivery and biomedical applications.
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