Abstract
Hanz Selye made the original description of stress syndrome. Since then anxiety, panic attacks, depression, unemployment, sleep deprivation, work stress, hostility and anger, posttraumatic stress, and family stresses, among others, have all been related to cardiovascular diseases. In particular, depression influences postmyocardial infarction evolution. Endothelial dysfunction was documented in several clinical studies with induced mental stress in normal individuals, patients with coronary artery disease, and the elderly. Acute heart attacks and sudden death have been attributed, at least in part, to acute emotional stress. Even adolescents subjected to continuous emotional stress have greater chance of developing cardiac conditions in later life. In addition, studies in animals showed that stress worsens endothelial function.
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