Abstract
The dental follicle surrounds the tooth germ during the early stages of tooth development, and plays a crucial role in tooth eruption and tooth development. During tooth development the dental follicle starts to disappear, and the residues of the dental follicle can be separated into a coronal part, which is in close vicinity to the developing periodontium and the tooth crown before tooth eruption, and a periapical part, which is located apically from the dental papilla. Since human dental follicles can be separated from impacted wisdom teeth with undeveloped tooth roots, undifferentiated ectomesenchymal cells can be isolated from both parts of the human dental follicle. These cells, which are also known as dental follicle precursor cells or dental follicle cells, are multipotent stem cells and a potential cell source for periodontal regeneration. This chapter will characterize the different types of dental follicle stem cells and their possible use in regenerative dentistry.
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