Abstract
Because of the genetic, metabolic, and physiological similarities to humans, nonhuman primates (NHPs) serve as excellent animal models for use in exploratory preclinical research and to assess the safety and efficacy of novel therapeutic approaches. Furthermore, recent advances in genetic engineering, including transgenic and genome editing technologies, have enabled the development of a wide variety of NHP models of human disease. Among NHPs, the common marmoset (Callithrix jacchus) is an ideal laboratory animal model with which to employ genetic engineering technologies because of their unique reproductive characteristics such as ovulation of multiple oocytes per cycle, reaching sexual maturity at an early age, a relatively short gestation period, and a nonseasonal breeding pattern. The genetically modified marmoset model is predicted to act as a critical intermediary that will accelerate the progression from basic research to the clinical application of technologies and therapeutics.
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