Chapter 2 - Palladacycles as Precatalysts for Heck and Sonogashira Cross-Coupling Reactions

Abstract

Alkenes and terminal alkynes are commonly available building blocks for a variety organic syntheses. The state-of-art transition metal-catalyzed Mizoroki-Heck and Sonogashira cross-couplings represent versatile and reliable protocols for further modification these molecules. In the past few decades, these reactions were found generally to proceed-well in the presence of homogenous palladium catalyst. Recent advancements showed that palladacycles become one of the most promising catalyst systems for these transformations. It should be attractive to note that the palladacyclic complexes are usually thermally stable and easily to be synthesized. This book chapter summarizes the recent developments on palladacycles for Mizoroki-Heck and Sonogashira cross-couplings. Some unique catalytic performances of the palladacycles in relevant transformations are also described.