Abstract
The lung arises from the laryngotracheal groove that evaginates into the surrounding splanchnic mesenchyme in human embryos. Recently, stem cell-derived organoid culture systems have been established and benefited from current advances in our understanding of stem cell behavior, biology, and microenvironment, including interacting signaling pathways and surrounding extracellular matrix. Organoids are a three-dimensional, self-organized aggregate of various types of cells that are cultured and grown within extracellular matrix protein-derived gels. Recent studies have shown that the organoid culture system is a powerful research tool to investigate cell biology/development as well as tissue repair and regeneration. In this chapter, we will discuss the applications of organoid culture techniques for modeling lung development. We will also describe and discuss current and potential organoid-based modality of lung cellular activities, processes, and functions, including lung branching morphogenesis and cell–cell interaction, and organoid culture techniques as a model for lung stem cell activities and functions.
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