Abstract
Recent advances in the characterization of organ-specific stem cell types and determination of both the functional roles of stem cell microenvironment and stem cell-niche cross talk have led to the development of reproducible organoid culture systems. These culture systems can recapitulate various in vivo condition(s) and, therefore, facilitate the investigation of the process of tissue repair and regeneration. Although they are still in their infancy, lung organoid cultures can be used to investigate the functions of lung-specific stem cells, monitor stem cell behavior in different microenvironments, and model lung diseases and therapy. In this chapter, we will discuss the role of lung organoid cultures as innovative test bed for basic and translational approaches and their regenerative potentials. In addition, we will discuss organoid culture models of lung cancer, pulmonary fibrosis, and obstructive lung diseases, and how lung organoids are innovative test bed for drug development, screening, and therapeutics.
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