Abstract
This chapter describes the general mechanism of cancer invasion and metastasis, and discusses the relationship between cancer cells, including prostatic carcinoma, and host stromal cells in cancer growth, invasion, and metastasis. A detailed discussion on the mechanism of and consider several growth factors related to osteoblastic metastasis from prostate cancer is also provided in this chapter. Prostate cancer is the most common malignant tumor among men in the United States. Most deaths from the disease are still caused by widespread metastases that are resistant to conventional treatment in spite of improved surgical techniques and local and systemic therapies. Human prostate cancer is one of the rare cancers that consistently produce osteoblastic metastasis to bone. The molecular basis for tumor progression, invasion, and metastasis is still unclear, although recent reports have emphasized the importance of secreted proteases, cellular molecules, and the presence of mitogenic and angiogenic growth factors at the sites of tumors. Cancer metastasis is established by a multistep mechanism, which is not understood in terms of single molecules. Prostate cancer shows unique metastatic behavior, chiefly osteoblastic bone metastasis, prior to other visceral metastases. Understanding the mechanism of osteoblastic bone metastasis is important for developing useful methods for the treatment of prostate cancer patients. More investigation is required for establishing new therapies for prostate cancer metastasis.
Published Version
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