Abstract
The current concept of membrane structure is based on the fluid mosaic model outlined by Singer and Nicolson in 1972. Not surprisingly, this model did not just spring to life in a fully developed form but instead was conceived slowly over centuries. This chapter discusses the two seemingly unrelated but parallel historical paths taken: the study of oil on water and the study of the cell outer barrier (plasma membrane). These two approaches did not converge until the classic experiment of Gorter and Grendel in 1925.
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