Abstract
The epidemiologic literature relating to hypertension in pregnancy has grown exponentially since Chesley’s 20-page chapter in the first edition of his 1978 treatise. New data characterize the occurrence, risk factors, predictors, natural history, and molecular epidemiology of preeclampsia. Those epidemiologic findings and the methods used to conduct them are critically assessed in this updated revision of the chapter. New evidence indicating that preeclampsia is a syndrome secondary to multiple pathophysiological pathways is presented. We address the heterogeneity among risk factors and clinical predictors that serve as “markers” of the disorder, but also consider the possibility that preeclampsia is a potential cause of future cardiovascular disease.
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