Abstract
Voltage-driven translocation through nanopores of charged molecules is described in this chapter. Based on description, brief introduction of charged surfaces and utilizing the Poisson–Boltzmann formalism, the concepts of electrostatic screening in ionic solutions are introduced. This formalism shows the relevant physical processes of driven DNA translocation DNA and is developed focusing on the interplay between electroosmosis, electrophoresis, and hydrodynamic interactions. After analyzing the entrance of DNA into a nanopore, force measurements are introduced that are able to clarify the mechanisms governing the translocation process. The chapter concludes with a brief discussion of forces in more complex geometries and briefly introduces numerical approaches needed to model real systems.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Engineered Nanopores for Bioanalytical Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
