Abstract
This chapter presents a survey of the applications of circular dichroism (CD) and optical rotatory dispersion (ORD) to the analysis of peptide conformation. These spectroscopic techniques have a unique sensitivity to molecular conformation and stereochemical relationships that makes them ideally suited to the detection of conformational differences and changes. In addition, both empirical and theoretical analyses can provide information about the absolute conformations in many cases. Especially when combined with other spectroscopic methods, such as nuclear magnetic resonance spectroscopy and Raman spectroscopy, and with conformational energy calculations, CD and ORD can be powerful probes into the conformation of peptides in solution. The chapter also discusses basic phenomenon of CD and ORD, wavelength dependence of optical rotation and CD, and general aspects of peptide CD and specific systems of cyclic peptides and the linear peptides.
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