Abstract
Endocrine disrupters, chemicals that interfere with normal hormone activity, may get into foods by several different routes, including food-packaging materials, environmental pollutants, and natural plant components. Regulatory assessments of chemical effects on reproduction require research data on gamete production, fertilization, fetal development, postnatal sexual development, and potential transgenerational effects. Several validated assays exist to test for possible endocrine disruptive effects at these different stages. However, strategic tools are needed to assess epigenetic effects emerging during later life stages caused by endocrine disrupter exposure during fetal or pubertal development. Current efforts at Health Canada are addressing the need for the collection of robust data sets that support linkages between genomic/proteomic and in vivo apical end points, as well as the integration of such data to further enhance risk assessment including the characterization and management of the potential risks associated with endocrine disruptors in food.
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