Abstract
Endocrine disrupters, chemicals that interfere with normal hormone activity, may get into foods by several different routes, including food-packaging materials, environmental pollutants, and natural plant components. Regulatory decisions regarding food additives and pesticides are based on files that are comparatively data-rich. However, food processing and cooking-induced chemicals, herbal remedies, and supplements can be data-poor, and one can see the complexity surrounding regulatory efforts when it comes to those chemicals in food. Assessments of chemical effects on reproduction require research data on gamete production, fertilization, fetal development, and postnatal sexual development. Several validated assays exist to test for possible endocrine disruptive effects at these different stages. However, strategies are needed to assess health or epigenetic effects emerging during later life stages by endocrine disrupter exposure during fetal or pubertal development.
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