Abstract
The kynurenine pathway is the main route of degradation of the essential amino acid tryptophan. The metabolites derived from kynurenine are well known to be implicated in multiple physiological events, as they play a fundamental role in the modulation of immune response, inflammation, cellular proliferation, and glutamatergic neurotransmission. Recently, the kynurenine pathway has gained relevance in neuroscience research, given its involvement in several neurodegenerative and mental disorders, including addiction processes. Regarding cannabis abuse, tetrahydrocannabinol and cannabidiol, along with some synthetic cannabinoids, have the ability of altering the kynurenine pathway. Interestingly, recent evidence has emerged on the effectiveness of modulation of the pathway for the treatment of the abuse and dependence of several drugs, including cannabis, thus revealing an exciting novel strategy against substance use disorders. In this chapter, we gather the latest evidence on the relationship between cannabis use and the kynurenine pathway.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Cannabis Use, Neurobiology, Psychology, and Treatment
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
