Abstract
Invadopodia and podosomes are ventral membrane protrusions formed by cancerous and non-cancerous cells, respectively. These closely resembling structures are enriched with actin filaments and matrix metalloproteases and have the ability to degrade the extracellular matrix. Studies over the last two decades have revealed that invadopodia/podosomes play pivotal roles in physiological and pathological processes that require remodeling of the extracellular matrix, such as cancer invasion and metastasis. Invadopodia/podosomes possess specialized membrane compositions and structures where dynamic membrane remodeling and trafficking occur. Recently, several membrane-associated and membrane-deforming proteins, such as Bin/Amphiphysin/Rvs (BAR) superfamily proteins, have been implicated in membrane shaping coupled with actin assembly at invadopodia/podosomes. Understanding the roles of these proteins in invadopodia/podosome provides new insights into the molecular mechanisms underlying the formation of these invasive structures and may identify potential therapeutic targets for the treatment of cancer invasion and metastasis.
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