Abstract
Lipoprotein receptors are evolutionarily ancient proteins that have a dual purpose as endocytic receptors for lipids, nutrients and other macromolecules, and as signal-transducing receptors that regulate a vast range of biologically essential mechanisms including metabolism, organ development, morphogenesis, angiogenesis, cell migration and inflammation. A subclass of lipoprotein receptors has been termed scavenger receptors for their ability to remove modified lipoproteins. This chapter focuses primarily on the low-density lipoprotein receptor gene family and its fascinating spectrum of diverse biological functions, and also gives a brief overview over the definition and classification of scavenger receptors.
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