Abstract
The encapsulation of bone marrow-derived stem cells in biodegradable hydrogels has provided attractive features for tissue engineering, including ease of operation, protection against immune rejection, and provision of a quasitissue environment for cellular and tissue growth within the body. In hydrogel scaffold design, conditions such as mechanical properties, swelling rate, degradation rate, and diffusion rate should be controlled. Decomposition rates may be adjusted by hydrolytic or enzymatic unstable composition in hydrogels or natural biopolymers sensitive to enzymatic degradation. Since the cells are present during the gelling process, the type of chemical structure of the hydrogel and the gelling process must be appropriate for cell survival in degradable hydrogels. In this chapter, we describe important considerations for cellular limitations and highlight recent advances in materials for encapsulation and applications in tissue engineering.
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