Abstract
Pediatric headache and pain disorders cause significant morbidity to children. Current treatments offer only modest efficacy with frequent side effects. Pediatric brain stimulation research can further understanding in the developmental neurobiology of pain and lead to safe and effective treatments. This chapter will outline the safety profiles of pediatric brain stimulation in headache and pain, also discussing headache neurostimulation pathophysiology and translation into adult clinical trials. Phosphene thresholds as a marker of occipital lobe excitability in migraine will also be covered. Brain stimulation modalities reviewed include the following invasive methods: deep brain stimulation, occipital nerve stimulation, and vagus nerve stimulation. Non-invasive methods discussed include: transcranial magnetic stimulation and transcranial direct-current stimulation. The chapter will conclude with potential directions for brain stimulation in pediatric headache and pain research.
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