Abstract
Porous particles have been widely used for lung delivery applications composed of various polymers and methods of fabrication such as salt-leaching, gas-foaming, and double-emulsion methods. These systems have been determined through numerous in vitro and in vivo studies to be effective in the delivery of pharmaceutical actives for the treatment of conditions such as asthma and chronic obstructive pulmonary diseases to cancer and diabetes. This can be attributed to their size, weight, and aerodynamic behavior. Through manipulation of these properties, varying sites in the pulmonary system have been targeted for condition-specific treatment and enhanced bioavailability. This chapter will therefore provide a review of the currently developed porous particulate systems. A brief overview on the pulmonary system and its effect on drug delivery has also been provided as well as the use of porous inhalable delivery systems compared with conventional intravenous formulations.
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