Abstract
Significant progress has been made over the last 20years in understanding the biology, pathology, and clinical management of nasopharyngeal carcinoma (NPC). The geographically restricted prevalence of NPC along with the crucial role of Epstein–Barr virus infection provides an excellent opportunity to study the interaction of environmental and genetic factors in cancer development. This chapter considers some of the basic science questions that remain unanswered. Much of this is concerned with how a virus that is the most common persistent infection in humans can contribute to a cancer with such a unique geography. NPC also provides an opportunity to consider how environmental factors impact the genetic and epigenetic landscape, and how the tumor microenvironment contributes to cancer. The study of NPC continues to provide insights into the carcinogenic process that are relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.
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