Abstract
The colloidal formulations of highly fluorinated compounds are recognised as useful tools for facilitating the controlled release of encapsulated hydrophobic drugs. The utility of fluorinated compounds is derived from their unique properties that are unmatched by their nonfluorinated counterparts. Fluorous colloids experience enhanced stability to afford longer vascular circulation time; in addition, highly fluorinated compounds are efficient ultrasound reflectors and exhibit high sensitivity in magnetic resonance imaging, allowing F-colloids to act as contrast agents for specific biochemical processes and tracers for cell tracking. This theranostic potential and the low hemolytic activity and cytotoxicity of fluorinated compounds corroborate their development as pharmaceutical drug delivery and imaging agents. This chapter will provide an overview of fluorous colloids and their development as pharmaceutical materials through the description of chemical and physical characteristics and the discussion of current research.
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